The new 'Proud to be Clear Assured' status has been awarded to the department, in recognition of its recruitment and retention of disabled talent.
This rating is part of an assessment programme launched by the Clear Company to help organisations identify barriers to the recruitment of disabled people.
The Clear Company highlighted several areas of best practice in the Home Office, including the level of support for disabled candidates and using alternative assessment methods such as work trials or working interviews to help see past the disability to the ability that lies beyond.
Ravi Chand, head of equality and diversity at the Home Office, said: "I am delighted that the Home Office has become the first ever organisation to achieve Clear Assured status.
"Like all government departments, the Home Office is going through a lot of internal redeployment. That's why it is vital to ensure that all our recruitment and retention processes are of the highest standard and becoming Clear Assured further demonstrates our disability confidence."
The achievement comes weeks after the Home Office was named 2011 employer of the year by Stonewall, the leading charity for lesbian, gay and bisexual people.
Minister for equalities Lynne Featherstone added: "It is essential that the Home Office represents and understands the communities we serve and recruits the brightest talents to do so.
"For this Government, the equalities agenda is about fairness: that is, equal treatment and equal opportunity. Becoming Clear Assured is further recognition that the Home Office is leading the way in ensuring equality is considered as a matter of course."