In the response, it states it's keen to ensure a "healthy balance between national oversight and assurance and what needs to be developed locally."
The response adds the body wants "top drawer" staff engagement, focusing on supporting and valuing staff.
The response is based on the views of hundreds of local employers and HR professionals who came together at several listening workshops held in February.
Dean Royles, chief executive of the NHS Employers organisation, said: "Making sure patients are our first priority all of the time and in every organisation will require a relentless focus on culture across the whole system and ensuring a more co-ordinated approach to sharing information across organisations to drive up standards."
"Developing organisational culture will also require locally driven change and engaging staff fully in the process."
The response also stated that regulation has a valuable role to play in protecting the public but it needs to mature and develop, use information more intelligently and become more responsive when issues arrive.
Embedding values locally, that are owned by staff, will help drive the cultural change required, the response said.
NHS Employers also said that building the confidence and assurance of the capability of healthcare assistants requires investment of resources into strengthening recruitment, selection, induction and development, rather than the creation of a national register.
Royles said: "The feedback we have received shows that there is an unwavering commitment from employers to ensure patients receive high quality care.
"We will continue supporting them to build upon the good work many have already undertaken around ensuring progressive people management practices, engaging staff, recruiting and managing against locally developed values and creating an open culture where staff feel supported and encouraged to raise concerns.
He added: "If we can respond in the right way then we can create an opportunity to really transform the care patients receive and the way we go about doing our work. That is the least we owe to the patients and the vast majority of staff who work tirelessly to deliver the highest standards of care.
"Success will be that 'Francis' becomes a byword for improvement rather than failure."
