The Fortune Global 500, an annual ranking of the top 500 corporations worldwide, shows that 40% of companies have their European headquarters in London. Paris has the second highest number of European HQs with just 8% of the Fortune 500.
Of all the high-skill workers in Europe's business capitals, 46% are based in London, the study found.
The figures suggest London has a larger concentration of skilled workers in Europe than New York does in North America; with 31% of North American skilled workers based in the Big Apple.
"London is a magnet for business and business people," said Deliotte London senior partnerKnowles-Cutler.
"One of our recent and related studies found that London leads the world when it comes to employing people in high-skill, knowledge-based sectors. Of the 22 high-skill sectors identified, London leads in 12 of these, employing 1.5 million people. New York employs 1.2 million (leading in seven) and Los Angeles 784,000."
London is also popular for non-European businesses looking for headquarters in Europe, with 60% choosing the city for their European base.
"The City has the highest number or skilled workers globally, higher than anywhere even in America or Asia," Knowles-Cutler said.
Knowles-Cutler added the reasons for this included the prominence of English as the language of business and the relative political and financial stability of the UK.
Boris Johnson, mayor of London, welcomed the results and called for a long-term strategy to ensure the city maintains its place as "the greatest city in the world."
Knowles-Cutler said the rise of the technology and media sectors in the City over the next five to seven years should help. But he warned that the cost of living was "the biggest threat" to London's position in the future.
